dc.contributor.author | Sandroff, Brian M. | |
dc.contributor.author | Wylie, Glenn R. | |
dc.contributor.author | Sutton, Brad P. | |
dc.contributor.author | Johnson, Curtis L. | |
dc.contributor.author | DeLuca, John | |
dc.contributor.author | Motl, Robert W. | |
dc.date.accessioned | 2019-02-22T13:13:15Z | |
dc.date.available | 2019-02-22T13:13:15Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Sandroff, B. M., Wylie, G. R., Sutton, B. P., Johnson, C. L., DeLuca, J., & Motl, R. W. (2018). Treadmill walking exercise training and brain function in multiple sclerosis: Preliminary evidence setting the stage for a network-based approach to rehabilitation. Multiple Sclerosis Journal - Experimental, Translational and Clinical. | nb_NO |
dc.identifier.uri | http://hdl.handle.net/11250/2587059 | |
dc.description.abstract | Exercise training has been identified as a highly promising approach for managing the cognitive consequences of multiple sclerosis (MS). This study represents a secondary analysis of resting-state functional connectivity (RSFC) magnetic resonance imaging data from a pilot treadmill walking exercise training intervention for improving cognitive processing speed (CPS) in MS. There were large intervention effects on RSFC between the thalamus and right superior frontal gyrus (d = 1.92) and left medial frontal gyrus (d = 1.70). There further were moderate-to-large intervention effects on CPS (d = 0.72). Such preliminary data highlight FC within thalamocortical circuitry as a potential target for rehabilitation interventions for improving CPS in cognitively impaired individuals with MS. | nb_NO |
dc.publisher | Multiple Sclerosis Journal – Experimental, Translational and Clinical | nb_NO |
dc.rights | Navngivelse-Ikkekommersiell 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/deed.no | * |
dc.subject | exercise | nb_NO |
dc.subject | cognition | nb_NO |
dc.subject | neuroimaging | nb_NO |
dc.subject | multiple sclerosis | nb_NO |
dc.subject | rehabilitation | nb_NO |
dc.subject | functional connectivity | nb_NO |
dc.title | Treadmill walking exercise training and brain function in multiple sclerosis: Preliminary evidence setting the stage for a network-based approach to rehabilitation | nb_NO |
dc.type | Journal article | nb_NO |
dc.source.volume | 4 | nb_NO |
dc.source.journal | Multiple Sclerosis Journal – Experimental, Translational and Clinical | nb_NO |
dc.source.issue | 1 | nb_NO |
dc.identifier.doi | http://dx.doi.org/10.1177/2055217318760641 | |